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The nonopioid results of tramadol are due to its ability to block the reuptake of monoamines, like norepinephrine (NE) and serotonin (5HT). Raises in NE are known to mediate your body's purely natural suffering-aid programs. Many of its discomfort-relieving results are as a result of enhanced levels of NE that act on alpha2 adrenergic receptors and